Description

21-Dehydro Flumethasone is a high-purity synthetic steroid derivative, serving as a key pharmaceutical intermediate. Its value lies in providing a critical building block for the research and development of advanced corticosteroid-based therapeutics. This compound is essential for manufacturers and R&D laboratories in the pharmaceutical and life sciences sectors, particularly those focused on anti-inflammatory and dermatological applications.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of potent corticosteroid APIs (Active Pharmaceutical Ingredients).
• Research & Development: Critical reference standard and starting material for novel drug discovery programs targeting inflammatory pathways.
• Veterinary Medicine: Used in the development of specialized anti-inflammatory treatments for animals.
• Dermatological Preparations: Serves as a precursor in the manufacture of high-potency topical creams and ointments.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor activity and steroid metabolism.
• Quality Control: Acts as a certified reference material (CRM) for analytical method development and validation in QC laboratories.

Basic Information

Product Name	21-Dehydro Flumethasone
CAS No.	65751-65-7
Molecular Formula	C22H27FO5
Molecular Weight	390.45 g/mol
Synonyms	9α-Fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-al; 21-Dehydroflumethasone; 21-Desoxyflumethasone; 1,4-Pregnadiene-9-fluoro-11β,17α,21-trihydroxy-16α-methyl-3,20-dione 21-aldehyde; Flumethasone 21-aldehyde; 9α-Fluoro-16α-methylprednisolone 21-aldehyde
EINECS	Contact for details

Quality Control

Our 21-Dehydro Flumethasone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.