Description

(6α,11β,16α,17α)-6,9-Difluoro-11-Hydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-3-Oxoandrosta-1,4-Diene-17-Carboxylic Acid is a high-purity synthetic steroid derivative with a complex, multi-functional molecular structure. This compound is a critical advanced pharmaceutical intermediate (API intermediate) valued for its precise stereochemistry and functional groups, which are essential for synthesizing potent corticosteroid analogs. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development and production of novel anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel topical and systemic corticosteroid drugs.
• Anti-inflammatory Drug Research: Used in R&D for developing new agents targeting inflammatory pathways with enhanced potency and selectivity.
• Immunosuppressant Development: Serves as a precursor for compounds under investigation for autoimmune disease treatment.
• Chemical Reference Standard: High-purity material for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial manufacturing of steroid-based APIs.
• Academic & Institutional Research: Used in biochemical and pharmacological studies to understand steroid receptor interactions and metabolism.

Basic Information

Product Name	(6α,11β,16α,17α)-6,9-Difluoro-11-Hydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-3-Oxoandrosta-1,4-Diene-17-Carboxylic Acid
CAS No.	65751-34-0
Molecular Formula	C24H28F2O7
Molecular Weight	466.47 g/mol
Synonyms	6α,9α-Difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-3-oxoandrosta-1,4-diene-17β-carboxylic acid; Difluoroprednisolone Acetonide-21-Carboxylic Acid; 17β-Carboxy-6α,9α-difluoro-11β-hydroxy-16α,17α-(isopropylidenedioxy)androsta-1,4-dien-3-one; Difluprednicarboxylic Acid Acetonide; CAS 65751-34-0; A related intermediate for Difluprednate.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality standards are designed to meet the rigorous demands of pharmaceutical development and cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. The original container should be kept sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.