Description

Nicocortonide is a synthetic corticosteroid derivative with potent anti-inflammatory and immunosuppressive properties. This compound is a critical intermediate in the synthesis of advanced topical and systemic pharmaceutical formulations. It is primarily utilized by research institutions and pharmaceutical manufacturers developing novel therapeutic agents for dermatological and inflammatory conditions. Our supply ensures high purity and batch-to-batch consistency for reliable R&D and production outcomes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel corticosteroid APIs for topical creams, ointments, and inhalers.
• Research & Development: Used in preclinical and clinical studies to investigate new anti-inflammatory drug candidates and delivery mechanisms.
• Dermatological Formulations: Serves as an active precursor in the development of treatments for psoriasis, eczema, and contact dermatitis.
• Veterinary Medicine: Employed in the development of anti-inflammatory treatments for companion and livestock animals.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control testing in laboratories.

Basic Information

Item	Detail
Product Name	Nicocortonide
CAS No.	65415-41-0
Molecular Formula	C24H31FO6
Molecular Weight	434.50 g/mol
Synonyms	Nicocortonide; 9α-Fluoro-11β,21-dihydroxy-16α,17α-(1-methylethylidene)bis(oxy)-pregna-1,4-diene-3,20-dione; 9α-Fluoro-11β,21-dihydroxy-16α,17α-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; 9α-Fluoro-16α,17α-isopropylidenedioxyprednisolone; 9α-Fluoro-16α,17α-(1-methylethylidene)bis(oxy)-11β,21-dihydroxypregna-1,4-diene-3,20-dione; Flunisolide related compound C (EP); Flunisolide Impurity C
EINECS	Contact for details

Quality Control

Our Nicocortonide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets stringent specifications for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.