Description

Mitoxantrone is a synthetic anthracenedione derivative with potent antineoplastic and immunosuppressive properties. This compound is a critical active pharmaceutical ingredient (API) valued for its efficacy in targeted therapeutic applications. It is primarily required by pharmaceutical manufacturers and research institutions engaged in oncology and immunology. Our supply ensures high purity and batch-to-batch consistency for reliable formulation and research outcomes.

Application

• Oncological Therapeutics: As a key API in the formulation of injectable chemotherapy drugs for treating certain leukemias, lymphomas, and advanced prostate cancer.
• Multiple Sclerosis Treatment: Used in the management of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis.
• Pharmaceutical Research & Development: Serves as a reference standard and a critical intermediate in the development of novel antineoplastic agents and drug delivery systems.
• Biochemical Research: Utilized in laboratory studies to investigate mechanisms of DNA intercalation, topoisomerase II inhibition, and cellular apoptosis.
• Veterinary Medicine: Potential application in veterinary oncology for the treatment of certain cancers in companion animals.

Basic Information

Product Name	Mitoxantrone
CAS No.	65271-80-9
Molecular Formula	C22H28N4O6
Molecular Weight	444.49 g/mol
Synonyms	Mitoxantrone Hydrochloride; DHAQ; Novantrone; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione; CL 232315; NSC 301739; 1,4-Dihydroxy-5,8-bis[2-[(2-hydroxyethyl)amino]ethylamino]anthra-9,10-quinone
EINECS	265-635-8

Quality Control

Our Mitoxantrone is manufactured and tested under strict quality management systems to meet the stringent requirements of pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and related substances tests. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications and supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at a controlled room temperature, typically between 15°C and 25°C. The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Blue-black crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.