Description

(Z)-4-Hydroxytamoxifen CAS NO 65213-48-1 is a potent, biologically active metabolite of the selective estrogen receptor modulator (SERM) Tamoxifen. This compound is of critical importance in pharmaceutical research and development, particularly for studying estrogen receptor pharmacology and breast cancer therapeutics. It is primarily required by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in oncology, endocrinology, and drug discovery programs.

Application

• Pharmaceutical Reference Standard: Serves as a primary analytical standard for the quantification and qualification of Tamoxifen and its metabolites in drug substance and product testing.
• Biochemical Research: Used as a high-affinity ligand in in vitro assays to study estrogen receptor (ER) binding, antagonism, and downstream signaling pathways.
• Metabolite Studies: Essential for pharmacokinetic and metabolic profiling studies to understand the biotransformation and activity profile of Tamoxifen therapy.
• Cell Culture & In Vitro Models: Applied in cell-based assays to investigate the effects of estrogen receptor modulation on cell proliferation, apoptosis, and gene expression in cancer cell lines.
• Method Development & Validation: Utilized in the development and validation of analytical methods, such as HPLC, LC-MS, and GC-MS, for bioanalytical and quality control laboratories.
• Preclinical Research: Employed in animal studies to model the efficacy and metabolic fate of SERM treatments, supporting Investigational New Drug (IND) applications.

Basic Information

Product Name	(Z)-4-Hydroxytamoxifen
CAS No.	65213-48-1
Molecular Formula	C26H29NO2
Molecular Weight	387.52 g/mol
Synonyms	4-Hydroxytamoxifen; (Z)-4-Hydroxytamoxifen; Afimoxifene; ICI 79280; (Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-buten-4-ol; Endoxifen; Metabolite B; Metabolite Y; trans-4-Hydroxytamoxifen (obsolete); Z-4-Hydroxytamoxifen
EINECS	Contact for details

Quality Control

Our (Z)-4-Hydroxytamoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR), and residual solvent analysis to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.