Description

N1-[3-[(4-Aminobutyl)Amino]Propyl]-13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-12-Hydroxybleomycinamide is a structurally complex bleomycin derivative, representing a key intermediate in the development of novel antitumor agents. This compound is of significant interest for its potential to be modified for enhanced therapeutic efficacy and reduced toxicity profiles in oncology research. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing next-generation chemotherapeutic drugs and targeted cancer therapies.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel bleomycin-based anticancer agents and antibiotic derivatives.
• Oncology Research: Used in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) and mechanisms of action against tumor cells.
• Drug Discovery & Development: Serves as a precursor for creating modified glycopeptide antibiotics with tailored properties for clinical applications.
• Bioconjugation Studies: The reactive amine groups enable conjugation with targeting moieties, antibodies, or drug delivery systems (e.g., nanoparticles, liposomes).
• Academic & Institutional Research: Employed in university and government labs for fundamental research on DNA cleavage and radiomimetic compounds.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Item	Details
Product Name	N1-[3-[(4-Aminobutyl)Amino]Propyl]-13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-12-Hydroxybleomycinamide
CAS No.	65057-91-2
Molecular Formula	C₅₈H₉₄N₂₀O₂₁S₂
Molecular Weight	1439.62 g/mol
Synonyms	Bleomycinamide derivative; 19-Demethyl-12-hydroxybleomycinamide derivative; Talopyranosyl bleomycin intermediate; Bleomycin A2 derivative; BLM derivative; 65057-91-2; N1-[3-[(4-Aminobutyl)amino]propyl]bleomycinamide
EINECS	Contact for details

Quality Control

Our N1-[3-[(4-Aminobutyl)Amino]Propyl]-13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-12-Hydroxybleomycinamide is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.