Description

1-(Difluoromethyl)-2-Nitrobenzene is a specialized aromatic compound featuring a difluoromethyl group ortho to a nitro substituent, making it a valuable fluorinated building block for advanced synthesis. This compound is critical for introducing the difluoromethyl moiety into target molecules, a key strategy in modern medicinal and agrochemical research to modulate physicochemical properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of novel drug candidates, particularly for incorporating the metabolically stable difluoromethyl group.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where fluorination enhances biological activity and environmental stability.
• Material Science Research: Employed in the synthesis of fluorinated organic materials, such as liquid crystals or polymers with tailored properties.
• Chemical Biology Probes: Acts as a building block for creating fluorinated probes and tags used in biochemical and diagnostic applications.
• Cross-Coupling Reactions: Functions as a substrate in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex, fluorinated biaryl systems.
• Nucleophilic Aromatic Substitution: The activated nitro group allows for further functionalization, enabling the synthesis of diverse heterocyclic and acyclic compounds.

Basic Information

Product Name	1-(Difluoromethyl)-2-Nitrobenzene
CAS No.	64747-65-5
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	2-Nitrobenzylidene Difluoride; α,α-Difluoro-2-nitrotoluene; o-Nitro-α,α-difluorotoluene; 2-Nitro-α,α-difluorotoluene; (Difluoromethyl)-2-nitrobenzene; 1-(Difluoromethyl)-2-nitrobenzene; 2-Nitrobenzal Difluoride; Benzene, 1-(difluoromethyl)-2-nitro-
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)-2-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.