Description

2-Bromo-4,5-Difluorobenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring bromine and fluorine substituents on a benzonitrile core, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro and bromo groups contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as semiconductors and liquid crystals, due to its electron-withdrawing character.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling the rapid diversification of chemical space.
• Fluorinated Compound Libraries: A valuable building block for medicinal chemistry programs focused on exploring the benefits of fluorination in drug design.

Basic Information

Product Name	2-Bromo-4,5-Difluorobenzonitrile
CAS No.	64695-82-5
Molecular Formula	C7H2BrF2N
Molecular Weight	218.00 g/mol
Synonyms	4,5-Difluoro-2-bromobenzonitrile; 2-Bromo-4,5-difluorobenzene carbonitrile; Benzonitrile, 2-bromo-4,5-difluoro-; 64695-82-5; 2-Bromo-4,5-difluorophenyl cyanide
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4,5-Difluorobenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.