Description

5,12-Naphthacenedione, 8-Acetyl-10-((2-Amino-2-Deoxy-β-D-Glucopyran Osyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy -1-Methoxy-, Hydrochlo Ride, (8S-Cis)- is a structurally complex, semi-synthetic anthracycline derivative of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a key intermediate or reference standard in the synthesis and quality control of novel chemotherapeutic agents. It is primarily needed by R&D laboratories, pharmaceutical manufacturers, and analytical service providers focused on oncology drug discovery and production.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel anthracycline-based anticancer drugs.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in pharmaceutical manufacturing.
• Biochemical Research: Serves as a tool compound for studying DNA intercalation mechanisms, topoisomerase II inhibition, and cellular apoptosis pathways.
• Academic Research: Utilized in university and institutional labs for investigating structure-activity relationships (SAR) of anthracycline derivatives.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for client-specific drug development projects.
• Impurity Standard: Acts as a certified reference material for identifying and quantifying related substances in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	5,12-Naphthacenedione, 8-Acetyl-10-((2-Amino-2-Deoxy-β-D-Glucopyran Osyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy -1-Methoxy-, Hydrochlo Ride, (8S-Cis)-
CAS No.	64397-29-1
Molecular Formula	C27H30ClNO12 • (x)HCl
Molecular Weight	Contact for details
Synonyms	8-Acetyl-10-((2-amino-2-deoxy-β-D-glucopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride; Aclacinomycin A derivative; Aclacinomycin A HCl analog; Anthracycline glycoside derivative; (8S-cis)-8-Acetyl-10-[(2-amino-2-deoxy-β-D-glucopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride; ACM-A related compound; 64397-29-1
EINECS	Contact for details

Quality Control

Our production of this high-purity pharmaceutical intermediate adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to ensure structural identity and purity. Certificates of Analysis (COA) detailing purity, impurities, and analytical results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccant or inert atmosphere packaging.

Specification

Item	Specification
Appearance	Orange to red-brown powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.