Description

Trifluoroacetyladriamycin-14-Octanoate is a chemically modified derivative of the anthracycline antibiotic doxorubicin, designed to enhance its pharmacological profile. This compound is of significant interest in advanced pharmaceutical research and development, particularly for creating prodrugs with improved stability, solubility, and targeted delivery. It serves as a critical intermediate for researchers and manufacturers in the fields of oncology drug discovery, medicinal chemistry, and the synthesis of novel anti-cancer therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel anthracycline-based prodrugs and targeted cancer therapies.
• Oncology Research: Used in preclinical studies to investigate structure-activity relationships (SAR) and to develop compounds with reduced cardiotoxicity.
• Medicinal Chemistry: Serves as a versatile scaffold for chemical modifications aimed at improving pharmacokinetic properties like bioavailability and tissue distribution.
• API (Active Pharmaceutical Ingredient) Development: Employed in the development and scale-up processes for new chemical entities (NCEs) in anti-cancer formulations.
• Bioconjugation Studies: Utilized in research focusing on antibody-drug conjugates (ADCs) or other targeted delivery systems due to its modifiable functional groups.
• Academic & Institutional Research: A valuable reagent for universities and research institutes studying anthracycline mechanisms and resistance.

Basic Information

Product Name	Trifluoroacetyladriamycin-14-Octanoate
CAS No.	64376-45-0
Molecular Formula	C₄₀H₄₆F₃NO₁₅
Molecular Weight	837.80 g/mol
Synonyms	14-Octanoyltrifluoroacetyladriamycin; Doxorubicin 14-Octanoate Trifluoroacetate; Trifluoroacetyl Adriamycin-14-Octanoate; 14-O-(Octanoyl)-N-trifluoroacetyladriamycin; Adriamycin-14-Octanoate Trifluoroacetyl Derivative; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione 14-Octanoate Trifluoroacetate
EINECS	Contact for details

Quality Control

Our Trifluoroacetyladriamycin-14-Octanoate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, purity, and impurity profiles. We adhere to relevant industry standards for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC/MS)	Conforms to structure
Identification (IR)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.