Description

8-Acetyl-10-[4-Amino-5-[3-Hydroxy-1-(1-Hydroxypropan-2-Yloxy)Butoxy]-6-Methyl-Oxan-2-Yl]Oxy-6,8,11-Trihydroxy-1-Methoxy-9,10-Dihydro-7H-Tetr Acene-5,12-Dione is a complex, high-purity anthracycline derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical advanced intermediate or reference standard for the synthesis of novel therapeutic agents, particularly in oncology. It is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing next-generation chemotherapeutics and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel anthracycline-based chemotherapeutic agents.
• Reference Standard: High-purity material for analytical method development, validation, and quality control in drug manufacturing.
• Biochemical Research: Tool compound for studying DNA intercalation mechanisms, topoisomerase II inhibition, and cellular apoptosis pathways.
• Anticancer Drug Discovery: Core scaffold for structure-activity relationship (SAR) studies to develop new oncology candidates with improved efficacy and reduced cardiotoxicity.
• Academic Research: Used in university and institutional labs for fundamental research on anthracycline pharmacology and drug resistance mechanisms.
• Process Chemistry Development: Serves as a model compound for optimizing complex multi-step synthetic routes under cGMP conditions.

Basic Information

Product Name	8-Acetyl-10-[4-Amino-5-[3-Hydroxy-1-(1-Hydroxypropan-2-Yloxy)Butoxy]-6-Methyl-Oxan-2-Yl]Oxy-6,8,11-Trihydroxy-1-Methoxy-9,10-Dihydro-7H-Tetr Acene-5,12-Dione
CAS No.	64253-71-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Anthracycline derivative intermediate; Doxorubicin related compound; 4'-O-Glycosylated anthracycline; 8-Acetyl-10-deoxy-13-dihydrodaunorubicin derivative; Amino sugar-modified anthracycline; 64253-71-0; (8S,10S)-8-Acetyl-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione (related IUPAC form)
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet client or regulatory requirements. We support development and commercial projects with a commitment to reliable supply and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when necessary to maintain stability and purity.

Specification

Item	Specification
Appearance	Orange to red-brown powder
Identification (HPLC)	Conforms to reference
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.