Description

2,5-Difluorobenzonitrile is a versatile fluorinated aromatic nitrile building block essential for advanced organic synthesis. Its molecular structure, featuring two strategically placed fluorine atoms, makes it a critical intermediate for introducing fluorinated motifs into target molecules, which is a key strategy in modern pharmaceutical and agrochemical development. This high-purity compound is primarily sought by research institutions and industrial manufacturers in the life sciences sector for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorobenzene core to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystals used in advanced display technologies.
• Organic Electronics: Employed in the research and production of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the properties of fluorinated compounds.

Basic Information

Item	Detail
Product Name	2,5-Difluorobenzonitrile
CAS No.	64248-64-2
Molecular Formula	C7H3F2N
Molecular Weight	139.10 g/mol
Synonyms	2,5-Difluorobenzene carbonitrile; 2,5-Difluorophenyl cyanide; Benzonitrile, 2,5-difluoro-; 2,5-Difluorobenzonitrile; 2,5-Difluorobenzyl nitrile (incorrect but common); 2,5-DFBN; 2,5-Difluorocyanobenzene
EINECS	Contact for details

Quality Control

Our 2,5-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.