Description

3,4-Difluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoro substitution pattern imparts specific electronic and steric properties. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystals used in display technologies.
• Polymer Chemistry: An intermediate for synthesizing specialty polymers and functional materials with unique thermal and chemical resistance properties.
• Organic Electronics: Employed in the research and development of organic semiconductors and electron-transport materials.
• Cross-Coupling Reactions: A versatile substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations to create biaryl systems.

Basic Information

Product Name	3,4-Difluorobenzonitrile
CAS No.	64248-62-0
Molecular Formula	C7H3F2N
Molecular Weight	139.10 g/mol
Synonyms	3,4-Difluorobenzene carbonitrile; 3,4-Difluorophenyl cyanide; Benzonitrile, 3,4-difluoro-; 3,4-DFBN; 3,4-Difluorobenzonitrile; 3,4-Difluorobenzonitrile (DFBN); 3,4-Difluorobenzyl nitrile (common misnomer); 1-Cyano-3,4-difluorobenzene
EINECS	Contact for details

Quality Control

Our 3,4-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and lot-to-lot consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.