Description

2-(Trifluoromethoxy)Benzonitrile is a versatile fluorinated aromatic nitrile building block, characterized by its trifluoromethoxy substituent which imparts unique electronic and steric properties. This compound is valued for its role in enhancing the metabolic stability, lipophilicity, and bioavailability of target molecules in advanced chemical synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve pesticidal activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and as a precursor for corresponding benzamides, benzoic acids, and heterocycles.
• Material Science Research: Investigated for the creation of novel polymers and advanced materials with specific thermal, chemical, or surface properties.

Basic Information

Product Name	2-(Trifluoromethoxy)Benzonitrile
CAS No.	63968-85-4
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	2-(Trifluoromethoxy)benzonitrile; α,α,α-Trifluoro-o-anisic acid nitrile; 2-Cyano-1-(trifluoromethoxy)benzene; o-(Trifluoromethoxy)benzonitrile; Benzonitrile, 2-(trifluoromethoxy)-; 2-Trifluoromethoxybenzonitrile
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and fluorides. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.