Description

2-(Difluoromethyl)-1-Fluoro-4-Nitrobenzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique difluoromethyl and nitro substituents make it a valuable precursor for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought by R&D chemists and process development scientists for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoromethyl group can enhance biological activity.
• Material Science Research: Serves as a monomer or precursor for synthesizing specialty polymers and liquid crystals with unique electronic or surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitutions, and reduction reactions to introduce fluorinated phenyl groups into target molecules.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	2-(Difluoromethyl)-1-Fluoro-4-Nitrobenzene
CAS No.	63878-71-7
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	1-Fluoro-2-(difluoromethyl)-4-nitrobenzene; 2-(Difluoromethyl)-4-nitrofluorobenzene; 4-Nitro-2-(difluoromethyl)fluorobenzene; 2,4-Difluoro-α,α-difluoro-5-nitrobenzene; 5-Nitro-2,4-bis(fluoromethyl)benzene (common name); α,α,2-Trifluoro-4-nitrobenzene; 63878-71-7; Benzene, 2-(difluoromethyl)-1-fluoro-4-nitro-
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethyl)-1-Fluoro-4-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.