Description

1-Fluoro-2-(Fluoromethyl)-4-Nitrobenzene is a specialized fluorinated aromatic nitro compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a fluorine atom and a fluoromethyl group on a nitrobenzene scaffold, makes it a valuable intermediate for introducing fluorine into complex molecules, which can dramatically alter their physical, chemical, and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced metabolic stability, bioavailability, and target selectivity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where fluorine incorporation improves efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and electronic materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitution, and reduction reactions to create complex, fluorinated molecular architectures.
• Research & Development: A valuable tool for academic and industrial R&D laboratories exploring structure-activity relationships (SAR) and new synthetic methodologies.

Basic Information

Product Name	1-Fluoro-2-(Fluoromethyl)-4-Nitrobenzene
CAS No.	63878-68-2
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	2-(Fluoromethyl)-1-fluoro-4-nitrobenzene; 4-Nitro-2-(fluoromethyl)fluorobenzene; 1-Fluoro-2-fluoromethyl-4-nitrobenzene; 2-Fluoromethyl-1-fluoro-4-nitrobenzene; 4-Nitro-α,α-difluorotoluene (related); Benzene, 1-fluoro-2-(fluoromethyl)-4-nitro-; α-Fluoro-2-fluoro-4-nitrotoluene
EINECS	Contact for details

Quality Control

Our 1-Fluoro-2-(Fluoromethyl)-4-Nitrobenzene is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical parameters. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound should be handled in accordance with good laboratory practices, and appropriate personal protective equipment should be worn.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.