Description

Cicloprolol CAS NO 63659-12-1 is a selective β-1 adrenergic receptor antagonist, commonly known as a β-blocker. This compound is of significant interest in pharmaceutical research and development for its potential cardiovascular applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, process development, and analytical method validation.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced β-blocker drug candidates and related cardiovascular agents.
• Biochemical Research: Used as a reference standard or active compound in studies investigating β-1 adrenergic receptor pharmacology and signal transduction pathways.
• Process Chemistry: Serves as a critical intermediate for scaling up production processes in GMP (Good Manufacturing Practice) environments.
• Analytical Development: Employed as a high-purity standard for developing and validating HPLC, LC-MS, and other analytical methods for quality control.
• Metabolite Studies: Utilized in the identification and synthesis of potential human or animal metabolites for pharmacokinetic and safety assessments.

Basic Information

Item	Detail
Product Name	Cicloprolol
CAS No.	63659-12-1
Molecular Formula	C15H22N2O3
Molecular Weight	278.35 g/mol
Synonyms	1-(4-Cyclopentylphenoxy)-3-[(1-methylethyl)amino]-2-propanol; (±)-Cicloprolol; Cicloprolol Hydrochloride (salt form); BRN 2938287; BDF-8935; ICI-89321; SC-13601; 2-Propanol, 1-(4-cyclopentylphenoxy)-3-[(1-methylethyl)amino]-
EINECS	Contact for details

Quality Control

Our Cicloprolol is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents, supporting compliance with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.