Description

4'-Deoxydaunomycin is a synthetic anthracycline derivative, structurally related to the potent anticancer agent daunorubicin. This compound is of significant interest in pharmaceutical research and development, particularly for its role as a key intermediate or reference standard in the synthesis and study of novel chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in oncology drug discovery, mechanism of action studies, and analytical method development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of more complex anthracycline-based anticancer drugs and their analogs.
• Biochemical Research: Used as a reference compound in studies investigating DNA intercalation, topoisomerase II inhibition, and the mechanisms of action of anthracycline antibiotics.
• Analytical Standard: Employed as a high-purity standard for quality control (QC) and quality assurance (QA) in pharmaceutical manufacturing, as well as for method validation in HPLC, LC-MS, and other analytical techniques.
• Drug Discovery & Development: Functions as a lead compound or a precursor for structure-activity relationship (SAR) studies aimed at developing new anticancer agents with improved efficacy or reduced side effects.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry, pharmacology, and cancer biology.

Basic Information

Product Name	4'-Deoxydaunomycin
CAS No.	63568-77-4
Molecular Formula	C₂₇H₂₉NO₁₀
Molecular Weight	527.52 g/mol
Synonyms	4'-Deoxy-13-dihydrodaunorubicin; 4'-Deoxydaunorubicin; 4'-Deoxy-13-dihydrodaunomycin; (8S,10S)-8-Acetyl-10-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione; 4'-Deoxy-13-dihydrodaunorubicin hydrochloride (salt form common); Daunorubicin, 4'-deoxy-13-dihydro-; Carminomycin I derivative
EINECS	Contact for details

Quality Control

Our 4'-Deoxydaunomycin is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC purity assays, spectroscopic identification (IR, NMR), and residual solvent analysis. Our quality systems are designed to support GMP-grade applications for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	Red to orange-red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.