Description

(8S,10S)-8-Acetyl-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-1-Methoxy-10-[(3-(Formylamino)-2,3,6-Trideoxy-α-L-Lyxo-Hexopyranosyl)Oxy]-5,12-Naphthacenedione is a structurally complex anthracycline derivative, a class of compounds renowned for their potent biological activity. This molecule is of significant interest for its role as a key intermediate or reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the synthesis and study of novel therapeutic agents, particularly in oncology.

Application

• Pharmaceutical Intermediate: Critical building block in the synthetic pathways for novel anthracycline-based chemotherapeutic agents.
• Biochemical Research: Used as a reference standard or probe in studies investigating DNA intercalation, topoisomerase II inhibition, and mechanisms of antibiotic/anticancer action.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories (HPLC, LC-MS).
• Academic Research: Utilized in university and institutional labs for chemical synthesis projects and structure-activity relationship (SAR) studies of natural product derivatives.
• Process Development: Employed in the development and scale-up of manufacturing processes for complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(8S,10S)-8-Acetyl-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-1-Methoxy-10-[(3-(Formylamino)-2,3,6-Trideoxy-α-L-Lyxo-Hexopyranosyl)Oxy]-5,12-Naphthacenedione
CAS No.	63084-42-4
Molecular Formula	C₂₈H₃₁NO₁₂
Molecular Weight	573.55 g/mol
Synonyms	10-[(3-(Formylamino)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; 8-Acetyl-10-[(3-formamido-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; Anthracycline derivative intermediate; 4-Demethoxy-7-O-methylnogalarol; 7-O-Methylnogalarol; 4-Demethoxy-7-O-methylnogarol; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical specifications. We support cGMP compliance for materials intended for pharmaceutical development and can tailor quality documentation to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The container should be kept in a dry, cool, and well-ventilated area. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.