Description

(6α,11β,16α)-6,9-Difluoro-11,21-Dihydroxy-21-Methoxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-Pregna-1,4-Diene-3,20-Dione CAS NO 62013-83-6 is a high-purity synthetic corticosteroid derivative, specifically a fluorinated pregnadiene. This compound is valued for its potent anti-inflammatory and immunosuppressive pharmacological activity, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily required by research institutions and pharmaceutical manufacturers developing next-generation topical and systemic corticosteroid therapies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent topical corticosteroids for dermatological conditions like eczema and psoriasis.
• Active Pharmaceutical Ingredient (API) Research: Used in preclinical and clinical research for developing new anti-inflammatory and immunosuppressive drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of steroid-based APIs.
• Biochemical Research: Used to study glucocorticoid receptor interactions and metabolic pathways in experimental models.

Basic Information

Item	Detail
Product Name	(6α,11β,16α)-6,9-Difluoro-11,21-Dihydroxy-21-Methoxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-Pregna-1,4-Diene-3,20-Dione
CAS No.	62013-83-6
Molecular Formula	C₂₆H₃₄F₂O₇
Molecular Weight	496.55 g/mol
Synonyms	Difluoroprednisolone Acetonide; 6α,9α-Difluoro-11β,21-dihydroxy-21-methoxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione; 6α,9α-Difluoro-11β-hydroxy-21-methoxy-16α,17α-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione; Difluoroprednisolone 21-Methyl Ether 16,17-Acetonide; NSC 394000; Fluorometholone related compound C (EP Impurity C)
EINECS	Contact for details

Quality Control

Every batch of our (6α,11β,16α)-6,9-Difluoro-11,21-Dihydroxy-21-Methoxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-Pregna-1,4-Diene-3,20-Dione is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Assay	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.