Description

Tixocortol is a synthetic corticosteroid derivative, specifically a glucocorticoid receptor agonist. This compound is of significant interest in pharmaceutical research and development due to its potent anti-inflammatory properties. It serves as a key intermediate or reference standard for the synthesis and quality control of advanced therapeutic agents. Industries requiring this material include pharmaceutical R&D, contract manufacturing organizations (CMOs), and analytical laboratories focused on steroid chemistry and drug metabolism studies.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel corticosteroid-based anti-inflammatory drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control (QC) and assurance (QA) in pharmaceutical manufacturing.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor (GR) binding affinity, mechanism of action, and metabolic pathways.
• Preclinical Development: Utilized in the formulation and testing of topical or systemic anti-inflammatory formulations during early-stage drug development.
• Metabolite Studies: Acts as a precursor or model compound for identifying and characterizing steroid metabolites in pharmacokinetic research.

Basic Information

Product Name	Tixocortol
CAS No.	61951-99-3
Molecular Formula	C22H31FO5S
Molecular Weight	426.54 g/mol
Synonyms	Pivalate; Tixocortol Pivalate; 11β,21-Dihydroxy-17α-[(methylsulfanyl)acetyl]oxy]pregna-1,4-diene-3,20-dione; SQ 26962; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(3,3-Dimethylbutyrate); Tiocortisol Pivalate; 11β-Hydroxy-21-[(3,3-dimethyl-1-oxobutoxy)-17α-[(methylthio)acetyl]oxy]pregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our Tixocortol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research materials. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided with every shipment. We support compliance with relevant guidelines for active pharmaceutical ingredients (APIs) and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.