Description

Clemastine CAS NO 61826-31-1 is a potent, selective histamine H1-receptor antagonist belonging to the ethanolamine class of antihistamines. This compound is critical for its reliable and effective anti-allergic properties, making it a key active pharmaceutical ingredient (API) in therapeutic formulations. It is primarily required by pharmaceutical manufacturers for the production of medications targeting allergic conditions such as hay fever, urticaria, and allergic rhinitis.

Application

• As the Active Pharmaceutical Ingredient (API) in prescription and over-the-counter antihistamine tablets and syrups.
• In the formulation of anti-allergy medications for the symptomatic relief of seasonal and perennial allergic rhinitis.
• For the treatment of urticaria (hives) and other allergic skin conditions.
• As a reference standard in pharmaceutical research and development for new allergy treatments.
• In quality control laboratories for analytical method development and validation.
• For use in preclinical and clinical studies evaluating histamine receptor antagonist efficacy.

Basic Information

Product Name	Clemastine
CAS No.	61826-31-1
Molecular Formula	C21H26ClNO
Molecular Weight	343.89 g/mol
Synonyms	Clemastine Fumarate (common salt form); Meclastin; Tavegil; Tavegyl; Tavist; 1-Methyl-2-[2-[(R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]pyrrolidine; (+)-(2R)-2-[2-[(R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine
EINECS	263-222-6

Quality Control

Our Clemastine is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each batch, confirming compliance with specified parameters. We can support development and regulatory filings with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.