Description

21-Dehydro Clocortolone is a key synthetic corticosteroid intermediate of significant importance in pharmaceutical research and development. Its primary value lies in its role as a precursor in the synthesis of more complex and potent steroid-based active pharmaceutical ingredients (APIs). This compound is essential for pharmaceutical companies and research institutions focused on developing advanced anti-inflammatory and dermatological treatments. The consistent quality and reliable supply of this intermediate are critical for ensuring the integrity of downstream manufacturing processes.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the multi-step synthesis of clocortolone pivalate and related corticosteroid APIs.
• Anti-inflammatory Drug Research: Serves as a key starting material or intermediate in R&D programs for novel topical corticosteroids.
• Dermatological Preparation Development: Used in the development of creams, ointments, and lotions targeting skin inflammation and conditions like eczema and psoriasis.
• Process Chemistry & Scale-up: Employed in process optimization and pilot-scale manufacturing of steroid compounds.
• Reference Standard: Can be utilized as a chromatographic reference standard for quality control and analytical method development.
• Academic & Institutional Research: Used in university and institutional labs for studying steroid chemistry, metabolism, and structure-activity relationships.

Basic Information

Product Name	21-Dehydro Clocortolone
CAS No.	61744-29-4
Molecular Formula	C22H27ClO4
Molecular Weight	390.90 g/mol
Synonyms	21-Dehydroclocortolone; 9-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9α-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione; Clocortolone Impurity; Clocortolone Related Compound A; 1,4-Pregnadiene-3,20-dione, 9-chloro-6-fluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)-; 21-Dehydro-clocortolone
EINECS	Contact for details

Quality Control

Our 21-Dehydro Clocortolone is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for demanding pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and related substances, identification by spectroscopic methods, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support our partners with full traceability and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.