Description

21-Dehydro Betamethasone is a key synthetic steroid intermediate, specifically a dehydrogenated derivative of the potent glucocorticoid betamethasone. This compound is of significant value in pharmaceutical research and development, serving as a crucial precursor for the synthesis of novel corticosteroid analogs and metabolites. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers engaged in the development of anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced corticosteroid drugs and their derivatives.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation.
• Metabolite Studies: Employed in pharmacological and toxicological research to study the metabolic pathways of betamethasone.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of steroid manufacturing processes.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor binding and activity.

Basic Information

Product Name	21-Dehydro Betamethasone
CAS No.	61558-12-1
Molecular Formula	C22H29FO5
Molecular Weight	392.46 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione; 21-Dehydrobetamethasone; δ21-Betamethasone; 1,4-Pregnadiene-9-fluoro-11β,17,21-triol-3,20-dione-16β-methyl; Betamethasone 21-Dehydro Derivative; NSC 119185
EINECS	Contact for details

Quality Control

Our 21-Dehydro Betamethasone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, identity, and impurity profiles to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.