Description

17-Bromo-9Beta,11Beta-Epoxy-6Beta-Fluoro-21-Hydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione is a high-purity, advanced steroid intermediate of significant importance in pharmaceutical research and development. This compound matters because it serves as a critical building block for synthesizing novel corticosteroid derivatives with potential therapeutic applications. Pharmaceutical companies and advanced research laboratories need this precise chemical entity to explore new drug candidates targeting inflammatory and autoimmune conditions.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent topical and systemic corticosteroid APIs (Active Pharmaceutical Ingredients).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new glucocorticoid receptor modulators with improved efficacy and safety profiles.
• Process Development: Employed in scaling up and optimizing synthetic routes for steroid-based pharmaceuticals in pilot plants and manufacturing settings.
• Reference Standard: Serves as an analytical standard for quality control and impurity profiling in steroid API production, ensuring batch-to-batch consistency.

Basic Information

Product Name	17-Bromo-9Beta,11Beta-Epoxy-6Beta-Fluoro-21-Hydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione
CAS No.	61339-44-4
Molecular Formula	C22H26BrFO5
Molecular Weight	469.35 g/mol
Synonyms	9β,11β-Epoxy-6β-fluoro-21-hydroxy-16α-methyl-17-bromopregna-1,4-diene-3,20-dione; 17-Bromo-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 11,21-diacetate (related ester); 17-Bromo-9,11-epoxy-6-fluoro-21-hydroxy-16-methylpregna-1,4-diene-3,20-dione; 6β-Fluoro-11β,21-dihydroxy-16α-methyl-17-bromopregna-1,4-diene-3,20-dione cyclic 11,21-acetal with formaldehyde; Brominated Fluocinolone Acetonide Intermediate; 17-Bromo Fluocinolone Acetonide Derivative
EINECS	Contact for details

Quality Control

Our 17-Bromo-9Beta,11Beta-Epoxy-6Beta-Fluoro-21-Hydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione is manufactured under strict quality systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.