Description

4-(Difluoromethyl)-1-Fluoro-2-Nitrobenzene is a high-purity, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. This compound matters because its unique difluoromethyl and nitro substituents make it a versatile precursor for introducing fluorine motifs into complex molecules, which is critical for modulating the physicochemical and biological properties of target compounds. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of specialty chemicals and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance bioavailability and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Fluorinated Polymer Modification: Employed to introduce fluorine atoms into polymer backbones or side chains, improving material properties like chemical resistance, thermal stability, and dielectric performance.
• Cross-Coupling Reactions: The nitro and halogen substituents make it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex biaryl systems.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and constructing diverse fluorinated compound libraries.

Basic Information

Product Name	4-(Difluoromethyl)-1-Fluoro-2-Nitrobenzene
CAS No.	61324-89-8
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	1-Fluoro-4-(difluoromethyl)-2-nitrobenzene; 2-Nitro-4-(difluoromethyl)fluorobenzene; 4-(Difluoromethyl)-2-fluoro-1-nitrobenzene; 2-Fluoro-4-(difluoromethyl)-1-nitrobenzene; 4-(Difluoromethyl)-2-fluoronitrobenzene; 2-Fluoro-α,α-difluoro-4-nitrobenzyl; 4-(Difluoromethyl)-1-fluoro-2-nitro-benzene
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethyl)-1-Fluoro-2-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the consistency and reliability required for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in a dark environment.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (HPLC/GC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC/GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.