Description

Pregna-1,4-Diene-3,20-Dione, 21-Chloro-9-Fluoro-11,17-Dihydroxy-16-Methyl-, (11β,16α)- (9Ci) is a high-purity synthetic steroid derivative, recognized for its role as a key pharmaceutical intermediate. Its value lies in providing a reliable and consistent building block for the synthesis of advanced corticosteroid APIs, ensuring downstream process integrity. This compound is essential for R&D and production teams in the pharmaceutical and fine chemical industries, particularly those developing anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent glucocorticoid drugs.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel corticosteroid-based medications.
• Biochemical Research: Serves as a reference standard or tool compound for studying steroid receptor interactions and metabolic pathways.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for specialized steroid derivatives.

Basic Information

Product Name	Pregna-1,4-Diene-3,20-Dione, 21-Chloro-9-Fluoro-11,17-Dihydroxy-16-Methyl-, (11β,16α)- (9Ci)
CAS No.	61319-46-8
Molecular Formula	C22H28ClFO5
Molecular Weight	426.91 g/mol
Synonyms	21-Chloro-9-fluoro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-chloro derivative; Clocortolone Impurity; Clocortolone Related Compound A; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-chloride; (11β,16α)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 21-Chloro-9-Fluoro-11,17-Dihydroxy-16-Methyl-, (11β,16α)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.