Description

2-Amino-5-Fluorobenzonitrile is a versatile fluorinated aromatic nitrile and aniline derivative, serving as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both an amino and a nitrile group on a fluorinated benzene ring, makes it an indispensable intermediate for constructing complex molecular architectures. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those targeting central nervous system disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Functional Material Research: Employed in the synthesis of organic semiconductors, liquid crystals, and dyes due to its electron-withdrawing nitrile and electron-donating amino groups.
• Chemical Biology Probes: Utilized to develop fluorescent tags and molecular probes for biochemical and diagnostic applications.

Basic Information

Product Name	2-Amino-5-Fluorobenzonitrile
CAS No.	61272-77-3
Molecular Formula	C7H5FN2
Molecular Weight	136.13 g/mol
Synonyms	5-Fluoro-2-aminobenzonitrile; 2-Amino-5-fluorobenzonitrile; 5-Fluoroanthranilonitrile; 2-Cyano-4-fluoroaniline; 4-Fluoro-2-aminobenzonitrile; Benzonitrile, 2-amino-5-fluoro-; 2-Amino-5-fluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product quality and stability. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.