Description

(S)-4-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]Phenol Hydrochloride is a high-purity chiral intermediate of significant pharmaceutical importance. This compound matters as a key building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), where stereochemical integrity is critical for efficacy and safety. It is primarily needed by pharmaceutical R&D laboratories and manufacturers developing or producing β-adrenergic blocking agents and other chiral therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of enantiomerically pure β-blocker APIs, such as (S)-propranolol and related analogs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key starting material or advanced intermediate in the research and process development of new cardiovascular drugs.
• Asymmetric Synthesis: Utilized in chiral pool synthesis and resolution processes to construct molecules with defined stereocenters.
• Biochemical Research: Used as a reference standard or ligand in studies investigating adrenergic receptor binding and function.
• Process Chemistry & Scale-Up: Employed in optimizing and scaling manufacturing routes for chiral pharmaceutical compounds under GMP conditions.

Basic Information

Product Name	(S)-4-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]Phenol Hydrochloride
CAS No.	61260-05-7
Molecular Formula	C12H20ClNO3
Molecular Weight	261.75 g/mol
Synonyms	(S)-1-Isopropylamino-3-(4-hydroxyphenoxy)-2-propanol Hydrochloride; (S)-4-(2-Hydroxy-3-isopropylaminopropoxy)phenol Hydrochloride; (S)-Propranolol Hydrochloride Impurity; (S)-ICI 45520 Hydrochloride; (S)-N-Isopropyl-4-(2-hydroxy-3-isopropylaminopropoxy)aniline Hydrochloride; (S)-(-)-4-[2-Hydroxy-3-(isopropylamino)propoxy]benzene Hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-4-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]Phenol Hydrochloride is manufactured under strict quality management systems. We provide material suitable for pharmaceutical R&D and process development, with a strong focus on chiral purity and chemical consistency. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and related substances are available for every batch. Our quality commitment ensures traceability and supports regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% (S-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤1.5%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.