Description

(±)-2-[4-[2-Hydroxy-3-(Isopropylamino)Propoxy]Phenyl]Acetamide CAS NO 60966-51-0 is a high-purity pharmaceutical intermediate and research chemical. This compound is of significant commercial interest due to its structural role as a key precursor in the synthesis of β-adrenergic blocking agents (β-blockers). It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in cardiovascular drug development, process chemistry, and analytical method validation.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of β-blocker APIs (Active Pharmaceutical Ingredients) such as propranolol and related analogs.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new cardiovascular therapeutics.
• Process Chemistry: Serves as a standard reference material and a starting material for scaling up production processes in pilot plants and commercial manufacturing.
• Analytical Standard: Employed as a certified reference standard in HPLC, LC-MS, and NMR for quality control and impurity profiling of final drug substances.
• Academic Research: Utilized in university and institutional labs for pharmacological studies and educational purposes in organic synthesis.

Basic Information

Product Name	(±)-2-[4-[2-Hydroxy-3-(Isopropylamino)Propoxy]Phenyl]Acetamide
CAS No.	60966-51-0
Molecular Formula	C14H22N2O3
Molecular Weight	266.34 g/mol
Synonyms	1-(Isopropylamino)-3-[4-(2-acetamidoethyl)phenoxy]-2-propanol; (±)-1-(Isopropylamino)-3-(p-(2-acetamidoethyl)phenoxy)-2-propanol; DL-1-(Isopropylamino)-3-[4-(2-acetamidoethyl)phenoxy]-2-propanol; Propranolol Intermediate; Propranolol Related Compound; 4-[2-Hydroxy-3-(isopropylamino)propoxy]phenethylacetamide; 2-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide
EINECS	Contact for details

Quality Control

Our production of (±)-2-[4-[2-Hydroxy-3-(Isopropylamino)Propoxy]Phenyl]Acetamide adheres to stringent quality management systems. The material is manufactured and tested to meet exacting standards suitable for pharmaceutical R&D and intermediate use. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques (HPLC, GC, NMR). We support compliance with cGMP and ICH guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.