Description

6Beta,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione is a high-purity synthetic corticosteroid intermediate of significant pharmaceutical importance. This compound is a key building block in the synthesis of potent topical anti-inflammatory and anti-pruritic medications. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in the development and production of dermatological creams, ointments, and other specialized steroid formulations. The precise fluorination pattern is critical for its biological activity and metabolic stability.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A crucial precursor in the multi-step synthesis of modern topical corticosteroids.
• Dermatological Formulations: Used in the manufacture of creams, ointments, and lotions for treating eczema, psoriasis, dermatitis, and other inflammatory skin conditions.
• Veterinary Pharmaceuticals: Employed in the development of anti-inflammatory treatments for animals.
• Pharmaceutical Research & Development: Serves as a reference standard and a key intermediate in the discovery of new steroid-based therapeutics.
• Process Chemistry & Scale-Up: Used in optimizing synthetic routes and scaling production for commercial pharmaceutical batches.

Basic Information

Product Name	6Beta,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione
CAS No.	60864-55-3
Molecular Formula	C21H26F2O6
Molecular Weight	412.43 g/mol
Synonyms	6β,9α-Difluoroprednisolone; 6β,9α-Difluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione; 6β,9α-Difluoro-δ1-hydrocortisone; Difluoroprednisolone; 9α,6β-Difluoroprednisolone; Fluocinonide Intermediate; 6β-Fluoro-9α-fluoroprednisolone
EINECS	Contact for details

Quality Control

Our 6Beta,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting specifications. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.