Description

9-Bromo-6Beta-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione is a high-purity synthetic steroid intermediate of significant importance in pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel corticosteroid derivatives with potential enhanced therapeutic profiles. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new anti-inflammatory and immunosuppressive agents. The precise bromo-fluoro substitution pattern on the pregnane skeleton makes it a valuable precursor for structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the multi-step synthesis of potent corticosteroid drugs.
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new glucocorticoid receptor agonists or antagonists.
• Process Chemistry: Employed in route scouting and scale-up studies for the production of steroid-based active pharmaceutical ingredients (APIs).
• Reference Standard: Serves as an analytical standard for quality control and impurity profiling in steroid API manufacturing.
• Biochemical Research: Utilized in studies investigating steroid hormone metabolism, receptor binding, and signal transduction pathways.

Basic Information

Product Name	9-Bromo-6Beta-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione
CAS No.	60864-54-2
Molecular Formula	C22H28BrFO5
Molecular Weight	471.36 g/mol
Synonyms	9-Bromo-6β-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9-Bromo-6-fluoro-16α-methylprednisolone; 9-Bromo-6-fluoromethylprednisolone; 9-Bromo-6-fluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione; 9-Bromoflumethasone intermediate; 9-Bromo-6β-fluoro-16α-methylprednisolone; 9-Br-6-F-16α-Me-Prednisolone
EINECS	Contact for details

Quality Control

Our 9-Bromo-6Beta-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity, the material should be stored under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.