Description

6Beta,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate) is a high-purity synthetic corticosteroid intermediate of significant pharmaceutical importance. This compound is a key building block in the synthesis of potent topical and systemic anti-inflammatory steroid APIs, valued for its precise fluorinated structure which enhances glucocorticoid receptor binding and metabolic stability. It is primarily required by pharmaceutical R&D laboratories and manufacturing facilities engaged in the production of advanced corticosteroid medications, including creams, ointments, and inhalable formulations.

Application

• Pharmaceutical Intermediate: Critical precursor in the multi-step synthesis of potent fluorinated corticosteroids like Difluprednate and related analogues.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a key raw material in GMP-compliant production processes for steroid-based drugs.
• Research & Development: Used in medicinal chemistry research for developing new anti-inflammatory and immunosuppressive agents with improved efficacy and safety profiles.
• Topical Corticosteroid Synthesis: Integral in manufacturing APIs for dermatological creams and ointments used to treat eczema, psoriasis, and dermatitis.
• Ophthalmic Drug Development: Employed in the research and production of steroid treatments for inflammatory eye conditions.
• Process Chemistry & Scale-Up: Used for process optimization and pilot-scale synthesis in pharmaceutical development.

Basic Information

Product Name	6Beta,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate)
CAS No.	60864-46-2
Molecular Formula	C₂₅H₃₀F₂O₇
Molecular Weight	480.50 g/mol
Synonyms	Difluprednate Intermediate; 6β,9α-Difluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-diacetate; 9α,6β-Difluoroprednisolone 17,21-diacetate; 6β,9α-Difluoro-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-diacetate; 6β,9α-Difluoroprednisolone 17,21-diacetate; 6β,9α-Difluoro-δ¹-prednisolone 17,21-diacetate; DFA; Contact for EINECS details.

Quality Control

Our 6Beta,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent chemical identity, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, related substances, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.