Description

9Beta,11Beta-Epoxy-6Beta-Fluoro-17,21-Dihydroxypregna-1,4-Diene-3,20-Dione is a high-purity synthetic steroid derivative, also known as a key fluorinated corticoid intermediate. This compound is of significant commercial importance due to its role as a critical building block in the synthesis of advanced pharmaceutical active ingredients. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of potent topical and systemic corticosteroids.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel fluorinated corticosteroid drugs, such as difluprednate and related analogs.
• Steroid Research: Used in academic and industrial R&D to study structure-activity relationships (SAR) of glucocorticoids, particularly the effects of fluorination and epoxidation on potency and metabolic stability.
• Process Chemistry Development: Serves as a reference standard and starting material for optimizing scalable manufacturing routes for anti-inflammatory APIs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Integrated into GMP production processes for final drug substances targeting inflammatory and autoimmune conditions.
• Analytical Standard: Employed as a high-purity certified reference material (CRM) for quality control testing, method validation, and regulatory submissions.

Basic Information

Product Name	9Beta,11Beta-Epoxy-6Beta-Fluoro-17,21-Dihydroxypregna-1,4-Diene-3,20-Dione
CAS No.	60864-43-9
Molecular Formula	C21H25FO6
Molecular Weight	392.42 g/mol
Synonyms	6β-Fluoro-9β,11β-epoxy-17,21-dihydroxypregna-1,4-diene-3,20-dione; 9β,11β-Epoxy-6β-fluoro-17α,21-dihydroxypregna-1,4-diene-3,20-dione; Difluprednate Intermediate; 6β-Fluoro-9β,11β-epoxy-17α,21-dihydroxypregna-1,4-diene-3,20-dione; 6β-Fluoro-9β,11β-epoxy-17α,21-dihydroxy-1,4-pregnadiene-3,20-dione; 6β-Fluoro-9β,11β-epoxy-17α,21-dihydroxy-1,4-pregnadiene-3,20-dione; 6β-Fluoro-9β,11β-epoxy-17α,21-dihydroxy-1,4-pregnadiene-3,20-dione; 6β-Fluoro-9β,11β-epoxy-17α,21-dihydroxy-1,4-pregnadiene-3,20-dione
EINECS	Contact for details

Quality Control

Our 9Beta,11Beta-Epoxy-6Beta-Fluoro-17,21-Dihydroxypregna-1,4-Diene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.