Description

9,11Beta-Dichloro-6Beta-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate) is a high-purity synthetic steroid derivative, primarily utilized as a critical pharmaceutical intermediate. Its complex halogenated structure makes it a valuable precursor in the synthesis of potent corticosteroid APIs, where precise molecular architecture is essential for biological activity. This compound is of significant interest to research institutions and pharmaceutical manufacturers focused on developing and producing advanced anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of advanced corticosteroid active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of novel steroidal drugs.
• Process Chemistry: Serves as a standardized intermediate for scaling up production processes under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.

Basic Information

Item	Detail
Product Name	9,11Beta-Dichloro-6Beta-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate)
CAS No.	60864-42-8
Molecular Formula	C₂₈H₃₄Cl₂FO₇
Molecular Weight	579.47 g/mol
Synonyms	9β,11β-Dichloro-6β-fluoro-16α-methylpregna-1,4-diene-3,20-dione 17,21-diacetate; 6β-Fluoro-9β,11β-dichloro-16α-methyl-1,4-pregnadiene-3,20-dione 17,21-diacetate; 17,21-Diacetoxy-9β,11β-dichloro-6β-fluoro-16α-methylpregna-1,4-diene-3,20-dione; Halogenated Corticosteroid Intermediate; 60864-42-8; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 9,11Beta-Dichloro-6Beta-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate) is produced and tested to meet the stringent requirements for pharmaceutical intermediates. We employ advanced analytical techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency across all batches. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.