Description

Methyl (1R,2R,4S)-4-[(2S,4S,5S,6S)-4-Dimethylamino-5-Hydroxy-6-Methyl-Oxan-2-Yl]Oxy-2-Ethyl-2,5,7-Trihydroxy-6,11-Dioxo-3,4-Dihydro-1H-Tetra Cene-1-Carboxylate is a complex, high-purity tetracycline derivative with a defined stereochemistry, making it a critical intermediate for advanced pharmaceutical synthesis. This compound is valued for its role in the research and development of novel antibacterial agents, particularly in creating next-generation tetracycline-class antibiotics to combat resistant strains. It is essential for pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on medicinal chemistry and antibiotic discovery.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel tetracycline antibiotics and semi-synthetic derivatives.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new antibacterial compounds with improved efficacy and reduced resistance.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in studies investigating the mechanism of action of tetracyclines and their interaction with bacterial ribosomes.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis for creating complex, biologically active molecules.

Basic Information

Product Name	Methyl (1R,2R,4S)-4-[(2S,4S,5S,6S)-4-Dimethylamino-5-Hydroxy-6-Methyl-Oxan-2-Yl]Oxy-2-Ethyl-2,5,7-Trihydroxy-6,11-Dioxo-3,4-Dihydro-1H-Tetra Cene-1-Carboxylate
CAS No.	60504-57-6
Molecular Formula	C₂₈H₃₇NO₁₂
Molecular Weight	579.60 g/mol
Synonyms	Methyl 4-(4-Dimethylamino-5-hydroxy-6-methyl-oxan-2-yl)oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate; (1R,2R,4S)-Methyl 4-[(2S,4S,5S,6S)-4-(Dimethylamino)-5-hydroxy-6-methyl-2-tetrahydropyranyl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-1,2,3,4-tetrahydro-1-tetracenecarboxylate; Tetracycline derivative intermediate; 6-Deoxy-6-demethyl-6-methylene-5-oxytetracycline methyl ester derivative; Antibiotic research intermediate
EINECS	Contact for details

Quality Control

Our Methyl (1R,2R,4S)-4-[(2S,4S,5S,6S)-4-Dimethylamino-5-Hydroxy-6-Methyl-Oxan-2-Yl]Oxy-2-Ethyl-2,5,7-Trihydroxy-6,11-Dioxo-3,4-Dihydro-1H-Tetra Cene-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, to ensure identity, potency, and the absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.