Description

(S)-(-)-1,2-Propanediol Di-p-Tosylate CAS NO 60434-71-1 is a high-purity chiral building block and key intermediate in advanced organic synthesis. Its value lies in its role as a versatile tosylating agent and protected chiral synthon, enabling the stereoselective construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure intermediates for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of chiral pesticides, herbicides, and fungicides where specific stereochemistry is required for biological activity and environmental safety.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing chiral ligands, catalysts, and auxiliaries used in asymmetric synthesis.
• Polymer Chemistry: Employed as a monomer or cross-linking agent for creating specialty polymers with specific chiral or functional properties.
• Academic and R&D Laboratories: A valuable reagent for method development and exploring new synthetic pathways in organic and medicinal chemistry research.
• Fine Chemical Production: Utilized in the multistep synthesis of complex fine chemicals, flavors, and fragrances requiring high stereochemical purity.

Basic Information

Product Name	(S)-(-)-1,2-Propanediol Di-p-Tosylate
CAS No.	60434-71-1
Molecular Formula	C19H22O6S2
Molecular Weight	410.50 g/mol
Synonyms	(S)-Propane-1,2-diyl bis(4-methylbenzenesulfonate); (S)-1,2-Propanediol ditosylate; (S)-1,2-Ditosyloxypropane; (S)-(-)-1,2-Di-O-tosylpropane-1,2-diol; (S)-Propylene glycol ditosylate; L-(-)-1,2-Propanediol di-p-toluenesulfonate; (S)-PGDTs; (2S)-2-Hydroxypropyl 4-methylbenzenesulfonate (1/1)
EINECS	Contact for details

Quality Control

Our (S)-(-)-1,2-Propanediol Di-p-Tosylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). The COA includes critical parameters such as chiral purity (HPLC), chemical purity (HPLC), and identification (IR, NMR). We are committed to meeting the stringent requirements of pharmaceutical and advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.