Description

Flumoxonide is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties. This compound is a critical intermediate in the synthesis of advanced pharmaceutical actives, valued for its specific glucocorticoid receptor activity. It is primarily utilized by research institutions and pharmaceutical manufacturers developing topical and systemic corticosteroid therapies for dermatological, respiratory, and autoimmune conditions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent topical corticosteroids for eczema, psoriasis, and dermatitis.
• Anti-inflammatory Drug Research: Used in preclinical and clinical research to develop new glucocorticoid receptor agonists.
• Veterinary Medicine: Component in formulations for treating inflammatory skin conditions in animals.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical labs.
• Biochemical Research: Tool compound for studying glucocorticoid signaling pathways and receptor interactions in cellular models.

Basic Information

Product Name	Flumoxonide
CAS No.	60135-22-0
Molecular Formula	C₂₇H₃₄F₂O₇
Molecular Weight	508.55 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate 17-butyrate; Flumoxonid; SQ-18571; Flumethasone 21-acetate 17-butyrate; Flumethasone pivalate (related compound); 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate 17-butyrate
EINECS	Contact for details

Quality Control

Our Flumoxonide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and stringent control of related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.