Description

Rac n-Demethyl Promethazine Hydrochloride is a key pharmaceutical intermediate and reference standard of significant importance in research and development. This compound is crucial for analytical and synthetic chemistry applications, particularly in the study of promethazine derivatives and their metabolites. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug development, quality control, and forensic analysis.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of promethazine and related phenothiazine derivatives.
• Analytical Reference Standard: Used for method development, validation, and quality control testing in HPLC, GC, and other chromatographic systems.
• Metabolite Studies: Essential for pharmacokinetic and metabolic pathway research of promethazine in biological systems.
• Impurity Profiling: Employed as a certified impurity standard to monitor and control the quality of active pharmaceutical ingredients (APIs).
• Research & Development: A vital reagent in medicinal chemistry for structure-activity relationship (SAR) studies and new drug discovery.
• Forensic Analysis: Used as a reference material in toxicology and forensic science for the identification of substances.

Basic Information

Product Name	Rac n-Demethyl Promethazine Hydrochloride
CAS No.	60113-77-1
Molecular Formula	C₁₇H₂₀N₂S•HCl
Molecular Weight	320.88 g/mol
Synonyms	N-Desmethylpromethazine Hydrochloride; (±)-N-Desmethylpromethazine HCl; Promethazine N-Oxide Impurity; 10H-Phenothiazine-10-ethanamine, N,α-dimethyl-, hydrochloride, (±)-; 1-Methyl-2-(10H-phenothiazin-10-yl)ethylamine Hydrochloride; Promethazine Metabolite; Norpromethazine Hydrochloride (racemic)
EINECS	Contact for details

Quality Control

Our Rac n-Demethyl Promethazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and NMR to ensure it meets stringent specifications for research and industrial use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.