Description

2,3-Difluoronitrobenzene is a versatile fluorinated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a difluoro-substituted benzene core.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides where the fluorine atoms enhance biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing compounds used in electronic display technologies.
• Polymer Modification: Intermediate for introducing fluorinated aromatic units into polymers to alter thermal, chemical, or surface properties.
• Cross-Coupling Reactions: Substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro and fluoro groups are excellent leaving groups for constructing heterocycles and complex aromatic systems.

Basic Information

Product Name	2,3-Difluoronitrobenzene
CAS No.	6921-22-8
Molecular Formula	C6H3F2NO2
Molecular Weight	159.09 g/mol
Synonyms	1,2-Difluoro-3-nitrobenzene; 3-Nitro-1,2-difluorobenzene; 2,3-Difluoro-1-nitrobenzene; Benzene, 1,2-difluoro-3-nitro-; 2,3-DFNB; NSC 404080; 2,3-Difluoronitrobenzene (technical grade)
EINECS	230-037-3

Quality Control

Our 2,3-Difluoronitrobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	30-34 °C
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.