Description

Pregna-1,4-Diene-3,20-Dione,11,17-Dihydroxy-6-Methyl-, (6A,11B)- CAS NO 6870-94-6 is a high-purity synthetic steroid intermediate of significant pharmaceutical importance. This compound serves as a critical building block in the synthesis of potent corticosteroid and progestogen APIs, valued for its precise stereochemistry and functional groups. It is primarily required by pharmaceutical R&D laboratories and manufacturing facilities for the development and production of advanced steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of methylprednisolone and related corticosteroid drugs.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel anti-inflammatory and immunosuppressant agents.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method validation in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization of steroid manufacturing pathways.
• Biochemical Research: Used in studies investigating steroid hormone receptor interactions and metabolic pathways.

Basic Information

Product Name	Pregna-1,4-Diene-3,20-Dione,11,17-Dihydroxy-6-Methyl-, (6A,11B)-
CAS No.	6870-94-6
Molecular Formula	C22H30O5
Molecular Weight	374.47 g/mol
Synonyms	6α-Methyl-11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione; 6α-Methylprednisolone; 6-Methylprednisolone; 11β,17α,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione; U-67590A; Medrol Intermediate
EINECS	229-973-6

Quality Control

Our Pregna-1,4-Diene-3,20-Dione,11,17-Dihydroxy-6-Methyl-, (6A,11B)- is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC, IR, and specific optical rotation to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet Pharmaceutical (USP/EP) or custom research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Specific Optical Rotation	+108° to +118° (c=1 in Dioxane)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.