Description

4-Pregnene-11Beta,17Alpha,21-Triol-3,20-Dione 21-Caprylate is a synthetic corticosteroid ester, specifically the 21-caprylate derivative of hydrocortisone. This compound is valued for its anti-inflammatory and immunosuppressive properties, offering a modified pharmacokinetic profile due to the esterification. It serves as a critical pharmaceutical intermediate for the synthesis of advanced topical and injectable corticosteroid formulations. Industries requiring high-purity steroid synthesis, such as pharmaceutical manufacturing and advanced research and development, rely on this specific intermediate for product development and scale-up.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of potent corticosteroid APIs (Active Pharmaceutical Ingredients).
• Topical Corticosteroid Formulations: Serves as a key precursor for creams, ointments, and lotions designed for dermatological applications.
• Injectable Steroid Prodrug Development: Used in research and production of long-acting injectable corticosteroid formulations.
• Anti-inflammatory Drug Research: A vital building block in medicinal chemistry for developing new steroidal anti-inflammatory agents.
• Veterinary Pharmaceutical Synthesis: Employed in creating anti-inflammatory treatments for animal health.
• Reference Standard: Used as an analytical standard in quality control laboratories for HPLC or GC method development and validation.

Basic Information

Product Name	4-Pregnene-11Beta,17Alpha,21-Triol-3,20-Dione 21-Caprylate
CAS No.	6678-14-4
Molecular Formula	C29H44O6
Molecular Weight	488.66 g/mol
Synonyms	Hydrocortisone 21-Caprylate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-octanoate; Cortisol 21-caprylate; 21-Octanoyloxycortisol; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, 21-octanoate; Cortisol octanoate; 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-octanoate
EINECS	Contact for details

Quality Control

Our 4-Pregnene-11Beta,17Alpha,21-Triol-3,20-Dione 21-Caprylate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing lot-specific results are available upon request, providing full traceability and compliance assurance for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.