Description

11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-Valerate is a synthetic corticosteroid derivative, specifically a valerate ester of hydrocortisone. This compound is a crucial pharmaceutical intermediate in the synthesis of more potent topical corticosteroids, valued for its anti-inflammatory and immunosuppressive properties. It is primarily required by manufacturers in the pharmaceutical and fine chemical industries for advanced drug development and production.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent topical corticosteroid APIs (Active Pharmaceutical Ingredients).
• Anti-inflammatory Drug Research: Used in R&D for developing new steroidal anti-inflammatory medications.
• Dermatological Preparations: Serves as a precursor for active ingredients in creams, ointments, and lotions for treating skin conditions like eczema and psoriasis.
• Veterinary Medicine: Employed in the formulation of anti-inflammatory treatments for animals.
• Biochemical Research: Used as a reference standard and probe in studies of glucocorticoid receptor activity and metabolism.
• Process Development: Utilized in scaling up and optimizing manufacturing processes for steroid-based therapeutics.

Basic Information

Item	Detail
Product Name	11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-Valerate
CAS No.	6678-00-8
Molecular Formula	C26H38O6
Molecular Weight	446.58 g/mol
Synonyms	Hydrocortisone 21-Valerate; Hydrocortisone Valerate; 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 21-valerate; Cortisol 21-Valerate; NSC 101791; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, 21-(1-oxopentyl)oxy)-, (11β)-; W 4869; Hydrocortisone 17-valerate (common misnomer)
EINECS	229-709-7

Quality Control

Our 11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-Valerate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, IR, and NMR, to ensure high purity and identity confirmation. We provide full traceability and Certificates of Analysis (COA) are available for every batch, supporting compliance with cGMP and other relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.