Description

Cortisol 21-Propionate is a synthetic corticosteroid ester, specifically the 21-propionate derivative of cortisol (hydrocortisone). This compound is a key pharmaceutical intermediate used in the synthesis of more potent and topically active steroid prodrugs. It is primarily utilized by manufacturers in the pharmaceutical and life science research sectors for developing anti-inflammatory and immunosuppressive medications. The precise chemical structure allows for targeted modification of pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of advanced corticosteroid APIs (Active Pharmaceutical Ingredients).
• Topical Corticosteroid Prodrug Development: Serves as a precursor for prodrugs designed for enhanced dermal absorption and localized activity.
• Anti-inflammatory Agent Research: Used in preclinical and research settings to study glucocorticoid receptor-mediated pathways.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or NMR.
• Biochemical Tool Compound: Utilized in metabolic and enzymatic studies related to steroid biochemistry.

Basic Information

Product Name	Cortisol 21-Propionate
CAS No.	6677-98-1
Molecular Formula	C24H34O6
Molecular Weight	418.53 g/mol
Synonyms	Hydrocortisone 21-propionate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-propionate; 21-Propionyloxycortisol; Cortisol propionate (21-); Cortisol 21-propanoate; Hydrocortisone propionate (21-ester); NSC 113927
EINECS	Contact for details

Quality Control

Our Cortisol 21-Propionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory standards (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤1.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.