Description

11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-Methanesulphonate is a high-purity steroid derivative, specifically the 21-methanesulfonate ester of hydrocortisone. This compound is a critical pharmaceutical intermediate valued for its role in the synthesis of more complex corticosteroid APIs and other specialized steroid-based molecules. It is primarily required by manufacturers in the pharmaceutical, biotechnology, and advanced fine chemical sectors for research and development as well as commercial production.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potent corticosteroid active pharmaceutical ingredients (APIs) and their prodrugs.
• Research & Development: Used in medicinal chemistry for the discovery and development of new anti-inflammatory and immunosuppressive agents.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control testing in laboratories.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor interactions and steroid metabolism pathways.
• Fine Chemical Synthesis: Utilized in the custom synthesis of novel steroid derivatives for various specialized applications.

Basic Information

Product Name	11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-Methanesulphonate
CAS No.	6677-96-9
Molecular Formula	C23H34O8S
Molecular Weight	470.57 g/mol
Synonyms	Hydrocortisone 21-Methanesulfonate; Hydrocortisone 21-Mesylate; Cortisol 21-Methanesulfonate; 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(methylsulfonate); Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, 21-(methylsulfonate), (11β)-; Cortisol 21-Mesylate; 21-O-Methanesulfonylcortisol
EINECS	Contact for details

Quality Control

Our 11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-Methanesulphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets exacting standards suitable for pharmaceutical R&D and intermediate use. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.