Description

Practolol CAS NO 6673-35-4 is a selective β-1 adrenergic receptor antagonist, historically significant in the development of cardioselective β-blockers. Its primary value lies as a key pharmaceutical intermediate and reference standard in cardiovascular research and drug development. This compound is essential for manufacturers and R&D laboratories focused on synthesizing or analyzing β-blocker medications, as well as for academic institutions conducting pharmacological studies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced β-adrenergic blocking agents.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of β-blocker APIs and finished dosage forms.
• Pharmacological Research: Serves as a tool compound in preclinical studies to investigate β-1 receptor selectivity, cardiac electrophysiology, and hemodynamic effects.
• Metabolite Studies: Employed in the identification and quantification of drug metabolites during pharmacokinetic and toxicological research.
• Academic & Educational Use: Utilized in university chemistry and pharmacology departments for teaching principles of medicinal chemistry and drug-receptor interactions.

Basic Information

Product Name	Practolol
CAS No.	6673-35-4
Molecular Formula	C14H22N2O3
Molecular Weight	266.34 g/mol
Synonyms	4-[2-Hydroxy-3-(isopropylamino)propoxy]acetamide; 1-(4-Acetamidophenoxy)-3-isopropylaminopropan-2-ol; ICI 50172; AY 21011; Eraldin; Dalzic; Cardiolol; Praktolol; Practololum
EINECS	229-704-7

Quality Control

Our Practolol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via techniques such as HPLC, IR, and NMR. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We can support development projects with material meeting research-grade or current Good Manufacturing Practice (cGMP) standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.