Description

2-Amino-5-Trifluoromethylbenzonitrile is a high-purity, versatile aromatic nitrile building block characterized by its amino and trifluoromethyl substituents. This compound is essential for the synthesis of complex molecules, where its unique trifluoromethyl group imparts desirable properties such as enhanced metabolic stability and lipophilicity. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in oncology, CNS, and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized colorants and imaging agents.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for creating complex biaryl structures.

Basic Information

Product Name	2-Amino-5-Trifluoromethylbenzonitrile
CAS No.	6526-08-5
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	2-Amino-α,α,α-trifluoro-p-tolunitrile; 2-Amino-α,α,α-trifluoro-4-methylbenzonitrile; 2-Cyano-4-(trifluoromethyl)aniline; 5-(Trifluoromethyl)-2-aminobenzonitrile; 2-Amino-5-(trifluoromethyl)benzonitrile; Benzonitrile, 2-amino-5-(trifluoromethyl)-; 4-Amino-3-cyano-α,α,α-trifluorotoluene
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Trifluoromethylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for industrial and research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.