Description

2,2,3,3-Tetrafluoropropyl Trifluoromethanesulfonate is a high-value fluorinated building block and reagent essential for advanced organic synthesis. Its core value lies in its powerful triflate leaving group and the unique reactivity imparted by the tetrafluoropropyl chain, enabling efficient introduction of fluorinated motifs. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing fluorinated active pharmaceutical ingredients (APIs) and prodrugs, leveraging the triflate group for C-O and C-N bond formation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where fluorination enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a critical building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving electronic properties and device performance.
• Polymer & Specialty Material Modifier: Employed to introduce fluorinated side chains into polymers, enhancing characteristics like chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: Acts as an effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to create complex biaryl and other structures.
• Nucleoside & Carbohydrate Chemistry: Utilized in the selective functionalization of nucleosides, nucleotides, and sugars for medicinal chemistry and biochemical research.

Basic Information

Product Name	2,2,3,3-Tetrafluoropropyl Trifluoromethanesulfonate
CAS No.	6401-02-1
Molecular Formula	C4H3F7O3S
Molecular Weight	264.12 g/mol
Synonyms	2,2,3,3-Tetrafluoropropyl Triflate; 3,3,4,4-Tetrafluorobutyl Trifluoromethanesulfonate; 1,1,1-Trifluoro-N-(3,3,4,4-tetrafluorobutyl)methanesulfonamide (related); Tetrafluoropropyl Triflate; Perfluoropropyl Triflate (common); CF3SO2OCH2CF2CF2H; Trifluoromethanesulfonic Acid 2,2,3,3-Tetrafluoropropyl Ester
EINECS	Contact for details

Quality Control

Our 2,2,3,3-Tetrafluoropropyl Trifluoromethanesulfonate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, GC/HPLC, and Karl Fischer titration, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.