Description

2,3,5,6-Tetrafluoronitrobenzene is a versatile fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its value lies in the strategic positioning of fluorine atoms and a nitro group, which makes it a key precursor for creating complex molecules with tailored electronic and physical properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), where fluorine substitution can enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve lipophilicity and environmental persistence.
• Liquid Crystal & Electronic Materials: Acts as a building block for fluorinated liquid crystals and organic semiconductors, where its structure contributes to desired dielectric and self-assembly properties.
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymer backbones, enhancing chemical resistance, thermal stability, and surface properties of high-performance plastics.
• Cross-Coupling Reactions: The nitro and halogen groups provide handles for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex biaryl systems.
• Nucleophilic Aromatic Substitution: The fluorine atoms are susceptible to displacement by various nucleophiles, enabling the efficient introduction of diverse functional groups onto the benzene core.

Basic Information

Product Name	2,3,5,6-Tetrafluoronitrobenzene
CAS No.	6257-03-0
Molecular Formula	C6HF4NO2
Molecular Weight	195.07 g/mol
Synonyms	1,2,4,5-Tetrafluoro-3-nitrobenzene; Nitro-2,3,5,6-tetrafluorobenzene; Benzene, 1,2,4,5-tetrafluoro-3-nitro-; 2,3,5,6-Tetrafluoro-1-nitrobenzene; 3-Nitro-1,2,4,5-tetrafluorobenzene; Perfluoronitrobenzene (common name for tetrafluoro derivatives); TFB-NO2 (abbreviation)
EINECS	228-416-9

Quality Control

Every batch of our 2,3,5,6-Tetrafluoronitrobenzene undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system is designed to support cGMP compliance for pharmaceutical development, ensuring traceability and consistency for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents and bases. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.