Description

3B,5Alpha-Tetrahydroaldosterone CAS NO 6251-41-8 is a key steroid derivative and a significant metabolite of aldosterone, a primary mineralocorticoid hormone. This compound is essential for research into the metabolic pathways, biological activity, and regulatory mechanisms of steroid hormones. It serves as a critical reference standard and intermediate for pharmaceutical development, particularly in studies related to hypertension, electrolyte balance, and endocrine disorders. Target users include research institutions, pharmaceutical R&D laboratories, and manufacturers of high-purity biochemical reagents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of aldosterone metabolites in analytical methods such as HPLC and LC-MS.
• Biochemical Research: Critical for in-vitro and in-vivo studies investigating the metabolism, catabolism, and biological half-life of aldosterone.
• Diagnostic Kit Development: Serves as a key antigen or calibrator in the development of immunoassays and ELISA kits for endocrine function testing.
• Metabolic Pathway Analysis: Employed in tracer studies to elucidate the complex biosynthetic and degradative pathways of corticosteroid hormones.
• Drug Discovery Intermediate: Acts as a sophisticated synthetic building block for the research and development of novel steroid-based therapeutics.
• Academic Research: Used in university and institutional labs for fundamental endocrinology and steroid chemistry research.

Basic Information

Product Name	3B,5Alpha-Tetrahydroaldosterone
CAS No.	6251-41-8
Molecular Formula	C21H32O5
Molecular Weight	364.48 g/mol
Synonyms	3β,5α-Tetrahydroaldosterone; 3β,5α-THA; 18,11-Hemiacetal of 3β,5α-tetrahydroaldosterone; 5α-Pregnane-3β,11β,21-triol-18,20-dione, cyclic 18,11-hemiacetal; 11β,21-Dihydroxy-3β,5α-pregnane-18,20-dione cyclic 18,11-hemiacetal; Aldosterone metabolite; Tetrahydro Aldosterone.
EINECS	Contact for details

Quality Control

Every batch of 3B,5Alpha-Tetrahydroaldosterone is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and impurity profile testing using advanced techniques like HPLC, NMR, and mass spectrometry to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA), detailing batch-specific results, is provided with each shipment to guarantee traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.